We sincerely thank the 928 peer reviewers who completed manuscript reviews for JAMA Internal Medicine in 2024.

This nonrandomized clinical trial investigates the association of a streamlined evaluation approach for patients undergoing kidney transplant with waitlisting and transplant likelihood.

In Reply In a Letter regarding our Viewpoint, Mercado discusses her involvement in implementing a firearm injury prevention (FIP) curriculum at Baylor College of Medicine. Mercado addresses the importance of understanding physicians’ role as “stakeholders in firearm injury prevention” and the merits of teaching clinical FIP techniques to all medical students. By offering strategies for institutions to begin to rectify the dearth of FIP programming in US medical schools, she highlights the importance of cross-institutional partnerships, faculty leadership, and, yes, medical student involvement.

This case-control study compares the availability of women’s health care clinicians in states that enacted highly restrictive abortion policy after the Dobbs Supreme Court decision vs states that established abortion legislation before the Dobbs decision.

This Guide to Statistics and Methods describes design, interpretation, and examples of a stepped-wedge cluster randomized trial.

The Original Investigation titled “Pain Coping Skills Training for Patients Receiving Hemodialysis: the HOPE Consortium Randomized Clinical Trial,” published online December 30, 2024, and in the February 2025 issue, has been updated to add a Nonauthor Collaborators Supplement including members of the HOPE Consortium. In Table 1, the overall number of patients and patients in the pain coping skills training group who had opioid use during the past 14 days were corrected to 162 (25.2%) and 81 (25.4%), respectively. These changes do not affect any of the analyses or results. This article has been corrected online.

Mission Statement: To advance the equitable, person-centered, and evidence-based practice of internal medicine through publication of scientifically rigorous, innovative, and inclusive research, review, and commentary that informs dialogue and action with clinical, public health, and policy impact.

This Viewpoint assesses prescription of medications to treat alcohol use disorder by primary care clinicians.

Health Care Policy

This cohort study examines the use of cholinesterase inhibitors and memantine among older adults with dementia after admission into hospice care despite the medications’ limited clinical benefit following enrollment into hospice.

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In Reply We appreciate the opportunity to respond to the Letter regarding our Teachable Moment in which Jolobe advocates for guideline-directed medical therapy (GDMT) in transthyretin amyloid cardiomyopathy (ATTR-CM). Although exploring traditional GDMT in this population is laudable, the evidence presented does not substantiate the conclusions, and it risks misapplication in clinical practice.

To the Editor Notwithstanding the documented intolerance of guideline-directed medical therapy (GDMT) in the Teachable Moment by Ayoola et al, measured uptitration of medication can mitigate the risk of intolerance of GDMT-related medications in patients with heart failure and transthyretin amyloid cardiomyopathy (ATTR-CM).

This Viewpoint discusses the critical importance of continued funding for the intramural research program in the Department of Veterans Affairs.

This quasi-experimental analysis examines the association between policy changes in Medicaid dental benefits and emergency department (ED) visits for nontraumatic dental conditions in California.

This randomized clinical trial assesses the efficacy of oral multivitamins and multiminerals in reducing cardiovascular events in patients with diabetes after a myocardial infarction.

Health Care Policy

This Viewpoint assesses an opportunity for epidemiological cohort study the Multi-ethnic Observational Study in American Asian and Pacific Islander Communities (MOSAAIC) to address critical evidence gaps for groups who have been labeled as “other” in research studies.

This population-based, cross-sectional study investigates avoidable mortality trends and health care spending in all US states compared with member countries of the European Union and Organisation for Economic Co-operation and Development.

This cohort study investigates associations of butter and plant-based oil intakes with risk of total and cause-specific mortality among US adults.

In the Research Letter titled “Kidney Transplantation Among Presumed Undocumented Immigrants After Changes in US State Policies,” published online November 11, 2024, and in the January 2025 issue, clarification was required in the first sentence of the Results. The first sentence given as “Presumed undocumented immigrants (median follow-up, 1.1 [IQR, 0.3-2.8] years) represented a higher proportion of patients listed during the postpolicy relative to the prepolicy period in crude (postpolicy, 62%; prepolicy, 38%) (Figure) and adjusted analyses (overall adjusted IRR, 2.21; 95% CI, 1.15-4.27)” should have been 2 sentences: “Among 576 presumed undocumented immigrants listed for transplantation (median follow-up, 1.1 [IQR, 0.3-2.8] years) in 3 states, 220 were listed prepolicy and 356 were listed postpolicy (Figure). Overall, presumed undocumented immigrants were more likely to be listed postpolicy than prepolicy (adjusted IRR, 2.21; 95% CI, 1.15-4.27).” This article has been corrected.

Kidney transplants can represent life-altering or even life-prolonging benefits to patients with end-stage kidney disease (ESKD). Yet, many of these patients are never placed on the kidney transplant waiting list and thus never receive kidney transplants. One step proximal to being placed on the waiting list is completion of the elaborate clinical evaluation required for patients being considered for kidney transplant.

The US is entering a time of great chaos and uncertainty in medicine, health care, and public health. Amid this background, the need for peer-reviewed scientific evidence has never been greater. JAMA Internal Medicine renews its unwavering commitment to providing this evidence base for medicine and health care and reaffirms its fundamental mission of advancing the equitable, person-centered, and evidence-based practice of internal medicine through publication of scientifically rigorous, innovative, and inclusive articles.

In this issue of JAMA Internal Medicine, Luo et al presented compelling evidence for awake prone positioning for patients with acute hypoxemic respiratory failure from COVID-19. Their meta-analysis based on individual patient data from 3019 patients in 14 randomized clinical trials demonstrated that awake prone positioning significantly improved survival without intubation and reduced both the risk of intubation and hospital mortality. The improved survival was most pronounced in individuals who had moderate to severe hypoxemia (pulse saturation to inhaled oxygen fraction ratio between 155 and 232), were younger than 68 years, had a body mass index between 26 and 30 (calculated as weight in kilograms divided by height in meters squared), and had prone positioning initiated within 1 day of hospitalization. Notably, patients who maintained prone positioning for at least 8.3 hours daily during the first 3 days of hospitalization had better outcomes than those with shorter prone times. This rigorous meta-analysis provides important evidence for managing critically ill patients with acute hypoxemic respiratory failure.

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