This review of meta-analyses examines data from meta-analyses reporting associations between social determinants of health and suicide-related outcomes to determine which factors are most strongly associated with suicide risk.

This cohort study of mental health treatment facilities examines whether service availability has changed since the launch of the 988 Suicide and Crisis Lifeline.

This cohort study uses electronic health record data of US individuals to evaluate whether there are patterns of comorbidity between intermittent explosive disorder and other conditions.

This case-control study analyzes genotypic and phenotypic information from individual-level UK Biobank data, along with genome-wide information from a large meta-analysis and the FinnGen cohort, to determine the relationship between traumatic experiences and endometriosis.

This Viewpoint discusses the regulatory and financial barriers to cannabis research, and the potential changes to these barriers if cannabis is reclassified as a Schedule III drug.

This Viewpoint discusses challenges related to ketamine use within psychiatry and offers recommendations for optimizing patient safety.

This cross-sectional study evaluates the efficacy of mental and substance use disorder treatments across 21 countries.

This randomized clinical trial evaluates the effectiveness of an intervention combining nicotine replacement with brief behavioral support in reducing cigarette use among adults with opioid dependency in Norway.

This narrative review provides guidance on designing and conducting trials that recruit high-risk patients, including choosing the proper clinical settings from which participants are recruited, designing a proper comparator group, selection of outcomes, ethical considerations, and management of regulatory oversight.

This case-control study analyzes published cases of lesion-induced psychosisTo assess whether lesions that cause secondary psychosis have functional connections to a common brain circuit

This randomized clinical trial assesses the effects of subcutaneous semaglutide on alcohol consumption in adults with alcohol use disorder.

Mapping human behavior to brain circuits has long been a goal for behavioral neurologists and neuropsychologists. Many discoveries were based on detailed psychological and anatomical studies of a single case. A famous example is Henry Gustav Molaison, better known as H.M.

The Original Investigation titled “Exploration-Exploitation and Suicidal Behavior in Borderline Personality Disorder and Depression,” published on October 2, 2024, was corrected to add a grant number to the Funding/Support section. This article was corrected online.

To the Editor Zhu identified significant US racial and ethnic fentanyl and polysubstance overdose death disparities. They astutely identified that American Indian or Alaska Native and Black populations experience the highest overdose death rates. However, as Pacific Islander health care professionals and researchers, we share concern for the continual aggregation of the Native Hawaiian and Pacific Islander population with the Asian American population when data exist as it obscures well-appreciated patterns of Native Hawaiian and Pacific Islander overdose deaths.

This Special Communication presents the arc of the author’s career as clinical scientist and mentor in old-age psychiatry.

Mission Statement: JAMA Psychiatry strives to publish original, state-of-the-art studies and commentaries of general interest to clinicians and researchers in psychiatry, mental health, behavioral science, and allied fields. The journal seeks to inform its readers, to stimulate discussion into the nature, causes, treatment, and public health importance of mental illness, and to promote equity and justice for those affected by mental illness and for society.