- Selective Antisense Oligonucleotide-based JAK2 Inhibitor Receives FDA Orphan Drug Designation for Polycythemia Vera
VGT-1849A could reduce JAK2 activity, lessening the disease burden faced by individuals with PV while providing a favorable safety profile.
- FDA Awards Fast Track Designation to Staphylococcus aureus Vaccine Candidate
Clinical trials will seek to evaluate the immunogenicity and safety of the LBT-SA7 vaccine.
- Research Shows Guillain-Barré Syndrome Remains Rare Among Older Adults After RSV Vaccination
Rates of GBS were similar between Arexvy and Abrysvo, at 0.12% and 0.11% of total reported events, respectively.
- FDA Issues Complete Response Letter for Much-Anticipated GLP-2 Analog
The medication, glepaglutide, is in development for the treatment of adults with short bowel syndrome with intestinal failure who are dependent on parenteral support.
- FDA Approves Premarket Approval Application for OraQuick HIV Self-Test, Expanding Access to Adolescents
OraQuick was the first at-home HIV test kit to be approved by the FDA in 2012.
- FDA Approves Alyftrek, Once-Daily CFTR Modulator for Cystic Fibrosis
The approval comes after clinical trial results in which vanzacaftor/tezacaftor/deutivacaftor (Alyftrek; Vertex Pharmaceuticals) demonstrated superiority compared with elexacaftor/tezacaftor/ivacaftor and ivacaftor (Trikafta; Vertex Pharmaceuticals).
- FDA Approves Tirzepatide as First Treatment for Moderate-to-Severe Obstructive Sleep Apnea in Adults With Obesity
The new approval continues to expand the therapeutic potential of GLP-1 medications such as tirzepatide, now being deemed effective in patients with obstructive sleep apnea.
- FDA Approves Expanded Use for Trikafta in Cystic Fibrosis
Vanzacaftor/tezacaftor/deutivacaftor (Alyftek) also received approval for the treatment of cystic fibrosis in people 6 years and older who have at least 1 F508del mutation.
- FDA Approves Expanded Indication for Setmelanotide to Include Patients 2 and Older
Setmelanotide is indicated to reduce excess body weight and maintain weight reduction long-term for patients with syndromic or monogenic obesity due to Bardet-Biedl syndrome.
- Study: Fatal Disseminated Herpes Zoster in Immunocompetent Individuals
Varicella-zoster vaccination could prevent fatal outcome among individuals with disseminated herpes zoster.
- Encorafenib With Cetuximab and mFOLFOX6 Receives Accelerated Approval for Patients With Metastatic Colorectal Cancer
The decision is based off favorable results from the BREAKWATER trial.
- ASHP Midyear: New Oral Treatment, Antibody Drug Conjugates Offer Additional Options for Breast Cancer
Pharmacists identify appropriate patients for new oral and antibody drug conjugate treatments and provide counseling to help patients navigate the evolving treatment landscape.
- Patients With Chronic Idiopathic Urticaria at Higher Risk of Developing Food Allergies
Knowing which patients are at higher risk for developing urticaria by analyzing their history of food allergies could lead to better outcomes in this population.
- FDA Affirms Decision on Tirzepatide Shortage Resolved, Sets Transition Period for Compounding
Compounding pharmacies have a 60- to 90-day grace period to complete production as it continues to monitor supply and demand.
- ASHP Midyear: Compounding Medications Provide Personalized Options for Patients
Compounding pharmacies play a vital role in meeting the unique needs of patients, but pharmacists must adhere to strict safety standards and regulations.
- FDA Approves Symvess for Treatment of Extremity Vascular Trauma
The approval follows positive results from the V005 (NCT03005418) clinical trial.
- Women With History of Gestational Diabetes Found to Have Less Inflammatory Diets
This could be attributed to improved diet and health awareness.
- Immune Checkpoint Inhibitor-Associated Nephritis: A Case of Nivolumab-Induced Acute Kidney Injury in a Patient with Urothelial Carcinoma
This case highlights the importance of recognizing ICPI-AKI, implementing effective therapeutic interventions, and understanding the clinical context to prevent irreversible renal damage.
- Important Background Information on RSV for Pharmacists
Traci M. Poole, PharmD, BCACP, BCGP, discusses the pathophysiology of respiratory syncytial virus (RSV) and its key complications, identifies high-risk populations for severe RSV infection, and explores best practices for recognizing these patients and ensuring they receive timely vaccination to prevent serious outcomes.
- Study: Predictive Screening Models Less Likely to Widen Existing Health Disparities in PMAD Diagnosis
The findings show a need for researchers and health care professionals to consider model designs to minimize disparities when diagnosing perinatal mood and anxiety disorders (PMADs).
- FDA Approves Olezarsen as Adjunct to Diet for Familial Chylomicronemia Syndrome
The rare genetic disease is a severe hypertriglyceridemia that can lead to potentially life-threatening acute pancreatitis.
- ASHP Midyear: Real-World Data Collection Helps to Facilitate Successful Biosimilar Adoption
The evolving regulatory policies around biosimilar interchangeability is crucial for driving successful biosimilar adoption in the marketplace.
- Treatment Advances for Alzheimer Disease Provide Hope
New mechanisms of action are proving more effective than ever, offering slowed progression.
- Phage Therapy: Exploring the Future of Infection Treatment
Phage therapy, which uses lytic bacteriophages to target antibiotic-resistant bacteria, has resurfaced as a promising treatment for multidrug-resistant infections, but faces challenges in regulation, production, and clinical implementation despite its growing evidence of efficacy.
- Dupilumab Improves Moderate-to-Severe Atopic Dermatitis in Young Children With Inflammatory Comorbidities
Proven effective in the treatment of atopic dermatitis (AD) and other allergic conditions, these study results confirm the ability of dupilumab to improve symptoms in children with other concurrent conditions.
- FDA Recalls 233,000 Bottles of Duloxetine Over Risk of Cancerous Chemical
Duloxetine is a commonly prescribed medication used to treat anxiety, depression, and other mental health disorders.
- Lactate-to-Albumin Ratio Predicts Development of ARDS, Mortality Risk From Flu
Previously, the evidence to support the prediction with lactate-to-albumin ratio has been unclear.
- Public Health Matters Video: The Importance of Reproductive Justice and Black Maternal Health
In this episode of Public Health Matters, Christina Madison discusses the concept of reproductive justice and ensuring Black maternal health efforts are not left behind with Regina Davis Moss of In Our Own Voice.
- FDA Approves Ensartinib for Anaplastic Lymphoma Kinase-Positive Non-Small Cell Lung Cancer
The indication is for patients with locally advanced or metastatic disease who have not previously received treatment with an ALK-inhibitor.