Drug-carrying DNA aptamers can deliver a one-two punch to leukemia by precisely targeting the elusive cancer stem cells that seed cancer relapses, researchers report. The aptamers -- short single-strand snippets of DNA that can target molecules like larger antibodies do -- not only deliver cancer-fighting drugs, but also are themselves toxic to the cancer stem cells, the researchers said.

Early administration of the drug Fosdenopterin/rcPMP improves the chances of survival of infants with MoCD type A and promotes the development of brain functions.

Researchers developed a manufacturing technique that rapidly generates large quantities of nanoparticles coated with drug-delivering polymers, which hold great potential for treating cancer. The particles can be targeted directly to tumors, where they release their payload while avoiding many of the side effects of traditional chemotherapy.

Researchers found that a small population of immune cells in the mouse intestine prevents allergic responses to food, suggesting that targeting such cells therapeutically could potentially lead to a new treatment for allergies.

In the fight against bacterial pathogens, researchers are combining vaccination with targeted colonization of the intestine by harmless microorganisms. This approach could potentially mark a turning point in the antibiotics crisis.

A team of researchers has uncovered a key cellular mechanism that affects the function of mRNA vaccines and therapeutics. Their study provides the first comprehensive understanding of how mRNA vaccines are delivered, processed, and degraded within cells -- a breakthrough that could pave the way for more effective vaccines and RNA-based treatments.

A powerful new software platform is set to transform biomedical research by allowing scientists to conduct complex and customized data analyses without advanced programming skills. The web-based platform enables scientists to analyze and visualize their own data independently through an intuitive, interactive interface.

While medical centers use ultrasound daily, so far this technology has not been capable of observing body tissues at the scale of cells. Physicists have now developed a microscopy technique based on ultrasound to reveal capillaries and cells across living organs -- something that wasn't possible before.

Researchers have developed a method that shows how the nervous system and sensory organs are formed in an embryo. By labeling stem cells with a genetic 'barcode', they have been able to follow the cells' developmental journey and discover how the inner ear is formed in mice. The discovery could provide important insights for future treatment of hearing loss.

New research shows that Sat Nav systems are helping keep older drivers on the roads for longer. The study reveals that over 65s with a poorer sense of direction rely more on help from GPS navigation systems such as Sat Nav or smartphone maps. Those using GPS tended to drive more frequently -- suggesting that the technology helps older people maintain driving independence.

A new CT-scan based risk score facilitates the identification of patients at risk of revision endoscopic sinus surgery due to chronic rhinosinusitis.

New research shines light on how the brain interprets nutritional and hydration needs and turns them into action.

Fluency in a foreign language is often thought to be about speaking quickly and using advanced vocabulary. However, researchers reveal that speakers who use common, everyday expressions sound more fluent than those who rely on rare, complex words. The study highlights the importance of mastering familiar phrases to improve fluency perception, suggesting that learners should naturally incorporate common formulaic expressions in spontaneous speech.

Parkinson's doesn't just affect movement and the brain -- it may also impact the heart, according to new research. Scientists suggest that targeting a key protein outside of the brain could help manage Parkinson's-related heart issues.

Certain antibiotic-resistant infections could be treated with precision medicine in the future, thanks to a new resource mapping plasmids the ultimate vehicle of rapid bacterial evolution.

A switch of just two weeks from a traditional African diet to a Western diet causes inflammation, reduces the immune response to pathogens, and activates processes associated with lifestyle diseases. Conversely, an African diet rich in vegetables, fiber, and fermented foods has positive effects. This study highlights the significant impact of diet on the immune system and metabolism.

For patients with polycystic kidney disease (PKD), a common genetic disorder that ravages the waste-removing organ with cysts, dialysis and transplantation are among the only treatments. More than 12.4 million people worldwide suffer from the dominant form of the condition. Now, geneticists have uncovered fresh details of how the disease progresses -- findings that could open the door to new therapies.

Scientists have shown that a sequence of just three amino acids may reduce the severity of psoriasis, when applied topically in an emollient cream.

There are over six million Americans with heart failure who are at greater risk of losing their cognitive abilities earlier in life, a study suggests. Global cognition and executive functioning declined more rapidly over the years after heart failure diagnosis, as people with the condition mentally aged the equivalent of 10 years within just seven years of a heart failure diagnosis.

In a new extensive systematic review, researchers identified 17 modifiable risk factors that are shared by stroke, dementia, and late-life depression. Modifying any one of them can reduce your risk of all three conditions. The findings provide evidence to inform novel tools such as the Brain Care Score.

Organoids have revolutionized science and medicine, providing platforms for disease modeling, drug testing, and understanding developmental processes. While not exact replicas of human organs, they offer significant insights. Scientists now present a new organoid model that reveals details of the developing nervous system's response to viral infections, such as Rubella. This model could influence pharmaceutical testing, particularly benefiting drug safety for pregnant women.

The technology described uses a nanomechanical platform and tiny cantilevers to detect multiple HIV antigens at high sensitivity in a matter of minutes. These silicon cantilevers are cheap and easy to mass produce and can be readily equipped with a digital readout. Built into a solar-powered device, this technology could be taken to hard-to-reach parts of the world where early detection remains a challenge to deliver fast interventions to vulnerable populations without waiting for a lab.

Cervical artery dissection is a tear in an artery in the neck that provides blood flow to the brain. Such a tear can result in blood clots that cause stroke. A new study has found almost a five-fold increase in the number of U.S. hospitalizations for cervical artery dissection over a 15-year period.

For the first time researchers demonstrate in an animal how heavy alcohol use leads to long-term behavioral issues by damaging brain circuits critical for decision-making.

When we move, it's harder for existing wearable devices to accurately track our heart activity. But researchers found that a starfish's five-arm shape helps solve this problem. Inspired by how a starfish flips itself over -- shrinking one of its arms and using the others in a coordinated motion to right itself -- scientists have created a starfish-shaped wearable device that tracks heart health in real time.